Modern Tools for the Synthesis of Complex Bioactive Molecules

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The focus of this proposal is to generate new enzymatic platforms for the synthesis of organofluorine molecules. With protein engineering techniques like directed evolution, we will bring fluorination activities into existing proteins that share mechanistic features with synthetic fluorination reactions.

These enzymatic platforms will expand the chemical space of biosynthesis tremendously and open up possibilities to develop whole new biosynthetic pathways for organofluorine synthesis. On their own, the enzymes developed would lead to highly efficient and selective synthetic routes to organofluorines that are currently unobtainable or feasible at scale.

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The structural and kinetic investigations of these new enzymes will greatly extend our understanding of enzymology and biochemistry to catalytic reactions unprecedented in nature. These new fluorination enzymes could be genetically incorporated into living hosts and coupled with existing biosynthetic pathways, enabling specific incorporation of fluorine groups into complex bioactive molecules.

These research efforts will empower the development of new fluorine-based therapeutics and provide a paradigm for bringing non-biological chemistries to life. The proposed research will develop two general enzymatic platforms for the efficient and selective synthesis of organofluorines.

Bioactive Molecules Profile from Natural Compounds

This research will broaden our fundamental understanding of biochemistry and enable cost-effective synthetic routes to new organofluorine compounds with high therapeutic potential. Toggle navigation.

The 16 chapters of the book Modern Tools for the Synthesis of Complex Bioactive Molecules , edited by Janine Cossy and Stellios Arseniyadis, describe the application of innovative modern synthetic methods and techniques in the preparation of natural products and other compounds of biological and pharmacological interest. Many impressive examples illustrate the importance of the described techniques.

Modern Tools for the Synthesis of Complex Bioactive Molecules : Janine Cossy :

As the book does not focus on specific narrow areas, not all chapters will be of equal interest for many readers—on the other hand, this selection provides an excellent opportunity to grasp good overviews about facets in natural products synthesis that may be less familiar to the reader. It shows the great power of modern catalysis and the elegant synthetic strategies derived therefrom.


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He warmly recommends the book to any student interested in the synthesis of complex compounds, and he is sure that experts in the field will discover interesting new aspects, as well. Please note that to comment on an article you must be registered and logged in. Registration is for free, you may already be registered to receive, e.